RESEARCH BLOG

July 17, 2018

Almost a decade ago, Manami Hara published a wonderful series of papers about species differences in the cell composition and cytoarchitecture of pancreatic islets (e.g. Steiner et al., 2010, Islets 2:135). The differences are really striking: cat and horse islets look...

To secrete insulin is what beta cells are made for. To do so, beta cells store insulin in granules that are released upon stimulation. This is a highly controlled process. Many signals such as blood sugar levels and hormones stimulate the beta cell. In response, beta c...

Stephan Speier and Marjan Rupnik developed the pancreas slice technique over a decade ago. In 2016, we implemented this technique in our lab because it can help us elucidate how islet cells interact with other cells in pancreatic regions bordering the islet. Also, in t...

Serotonin has been around for a while as a paracrine signal in the islet. Recent studies point to a role of serotonin mainly, if not exclusively, under conditions of increased metabolic demand, such as obesity and pregnancy. We now show that serotonin is produced and r...

June 1, 2013

Many laboratories are studying the expression of genes in the pancreatic islet to understand what goes wrong during the development of diabetes. To localize gene expression to the different cell types in the islet we perform in situ hybridization studies. We use probes...

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Division of Endocrinology, Diabetes and Metabolism

Department of Medicine

University of Miami Miller School of Medicine

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