University of Miami
Caicedo Group
The islet is the functional unit of the endocrine pancreas
PUBLICATIONS





Selected Publications (since 2014)

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Protocol to generate and utilize pancreatic tissue slices to study endocrine and exocrine physiology in situ from mouse and human tissue. (2023) STAR Protocols, 4:102399.
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A Defect in Mitochondrial Complex III but Not in Complexes I or IV Causes Early β-Cell Dysfunction and Hyperglycemia in Mice. (2023) Diabetes, 72:1262-1276.
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Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice. (2022) Diabetes, 71:1679-1693.
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Restoring glutamate receptor signaling in pancreatic alpha cells rescues glucagon responses in type 1 diabetes. (2022) Cell Reports, 41:111792.
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Pancreatic β-Cells Communicate With Vagal Sensory Neurons. (2021) Gastroenterology, 160:875-888.
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Mechanisms and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell. (2019) Nature Metab, 1:1110-1126.
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The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow. (2018) Cell Metab, 27:630-644.
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Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point. (2018) Cell Metab, 27:549-558.
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Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity (2017). Diabetologia, 61:182-192.
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β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions (2017). Nat Commun, 8:14295.
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Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets (2017). Lab Chip, 17:772-781.
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Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells (2016). Cell Reports, 17:3281-3291.
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Liraglutide compromises pancreatic β cell function in a humanized mouse model (2016). Cell Metabolism, 23:541:546.
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Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets (2015). Diabetologia, 58:2810-2818.
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Young capillary vessels rejuvenate aged pancreatic islets (2014). Proc Natl Acad Sci USA, 111:17612-7.