University of Miami
Caicedo Group
The islet is the functional unit of the endocrine pancreas
PUBLICATIONS
Selected Publications (since 2011)
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Mechanisms and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell. (2019) Nature Metab, 1:1110-1126.
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The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow. (2018) Cell Metab, 27:630-644.
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Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point. (2018) Cell Metab, 27:549-558.
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Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity (2017). Diabetologia, 61:182-192.
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β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions (2017). Nat Commun, 8:14295.
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Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets (2017). Lab Chip, 17:772-781.
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Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells (2016). Cell Reports, 17:3281-3291.
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Liraglutide compromises pancreatic β cell function in a humanized mouse model (2016). Cell Metabolism, 23:541:546.
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Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets (2015). Diabetologia, 58:2810-2818.
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Young capillary vessels rejuvenate aged pancreatic islets (2014). Proc Natl Acad Sci USA, 111:17612-7.
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Control of insulin secretion by cholinergic signaling in the human pancreatic islet (2014). Diabetes, 63:2714-2726.
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Paracrine and autocrine interactions in the human islet: More than meets the eye (2013). Semin Cell Dev Biol, 24:11-21.
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Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function (2012). Proc Natl Acad Sci USA, 109:21456-21461.
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Real time detection of acetylcholine release from the human endocrine pancreas (2012). Nature Protocols, 7:1015-23.
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Alpha cells secrete acetylcholine as a non- neuronal paracrine signal priming human beta cell function (2011). Nature Medicine, 17:888-892.
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Autonomic axons in the human endocrine pancreas show unique innervation patterns (2011). Cell Metabolism, 14:45-54.